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Avapritinib

CAS No. : 1703793-34-3

Biological Activity：Avapritinib (BLU-285) is a highly potent, selective, and orally active KIT and PDGFRA activation loop mutant kinases inhibitor with IC₅₀s of 0.27 and 0.24 nM for KIT D816V and PDGFRA D842V, respectively. Avapritinib (BLU-285) binds the active conformation of the kinase and shows antitumor activity. Avapritinib (BLU-285) attenuates the transport function of both ABCB1 and ABCG2^[2].

Research Area：Cancer

Targets：c-Kit|PDGFR

Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library Mini;Bioactive Compound Library Plus;Kinase Inhibitor Library;Protein Tyrosine Kinase Compound Library;FDA-Approved Drug Library;Anti-Cancer Compound Library;Drug Repurposing Compound Library;Reprogramming Compound Library;Anti-COVID-19 Compound Library;Orally Active Compound Library;FDA Approved & Pharmacopeial Drug Library;Anti-Blood Cancer Compound Library;Targeted Therapy Drug Library ;Angiogenesis-Related Compound Library;Anti-Liver Cancer Compound Library ;Rare Diseases Drug Library;Children’s Drug Library;FDA-Approved Anticancer Drug Library;Human Metabolite Library;Anti-Pulmonary Fibrosis Compound Library;

Related Small Molecules:Henatinib;c-Kit-IN-5-1;Flumatinib mesylate;IHMT-TRK-284;PDGFRα/FLT3-ITD-IN-2;PP58;Chiauranib;Zeteletinib;Pexidartinib;ENMD-2076 Tartrate;AZD2932;AC710 Mesylate;Tyrosine kinase-IN-1;Tandutinib;JNJ-10198409;SU4984;SU4312;MELK-8a;Masitinib

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