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Aurintricarboxylic acid
CAS No. : 4431-00-9
Biological Activity：Aurintricarboxylic acid is a nanomolar-potency, allosteric antagonist with selectivity towards αβ-methylene-ATP-sensitive P2X1Rs and P2X3Rs, with IC50s of 8.6 nM and 72.9 nM for rP2X1R and rP2X3R, respectively. Aurintricarboxylic acid is a potent anti-influenza agent by directly inhibiting the neuraminidase[2]. Aurintricarboxylic acid is an inhibitor of topoisomerase II and apoptosis[3]. Aurintricarboxylic acid is a selective inhibitor of the TWEAK-Fn14 signaling pathway[4]. Aurintricarboxylic acid also acts as a cystathionine-lyase (CSE) inhibitor with an IC50 of 0.6 μM[5]. Aurintricarboxylic acid is a modifier of miRNAs that regulate miRNA function, with an IC50 of 0.47 µM[6].
Research Area：Infection|Inflammation/Immunology|Neurological Disease
Targets：Topoisomerase|MicroRNA|Influenza Virus|P2X Receptor|Apoptosis
Related Screening Libraries:Bioactive Compound Library Plus;Anti-Infection Compound Library;Apoptosis Compound Library;Cell Cycle/DNA Damage Compound Library;Epigenetics Compound Library;Immunology/Inflammation Compound Library;Membrane Transporter/Ion Channel Compound Library;Antiviral Compound Library;Anti-Aging Compound Library;Neurotransmitter Receptor Compound Library;Anti-Lung Cancer Compound Library;Anti-Blood Cancer Compound Library;Protein-protein Interaction Inhibitor Library;Human Metabolite Library;
Related Small Molecules:Physalin A;Bomedemstat ditosylate;Gepotidacin;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;BJE6-106;Dinaciclib;Ecteinascidin 770;MDM2-p53-IN-15;AT9283;Staurosporine;Gefapixant citrate;SNS-032;C188-9;ZLDI-8;Topoisomerase I/II inhibitor 3;Xevinapant;Mangiferin;Cambinol;Antioxidant agent-5;Apoptosis inducer 9;Bafetinib;Cyclovirobuxine D
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