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Antifungal agent 22
CAS No. : 2640054-39-1
Biological Activity：Antifungal agent 22 (compound D16) is a potential and orally active antifungal agent for CM (cryptococcal meningitis), with an IC50 of 0.5 μg/mL. Antifungal agent 22 can penetrate the blood-brain barrier and kill the C. neoformans H99 cells by destroying the integrity of fungal cell membranes. Antifungal agent 22 shows selective anti-Cryptococcus activity with good metabolic stability and low cytotoxicity.
Research Area：Infection
Targets：Fungal
Related Small Molecules:Antifungal agent 20;Debneyol;Haloprogin;Staurosporine;Ciclopirox-d11;Ciclopirox olamine;Clotrimazole-d5;(R)-Camptothecin-d5;Ticlatone;Aminothiazole;Magnesium silicate;α-Terpinene;Hydroxyphenyllactic acid;Iprobenfos;Chlorphenesin;Moniliformin sodium salt;HLF1-11;β-Amyrin acetate;Bifonazole;Aszonapyrone A;Oenothein B;Pyrimorph;(+)-Magnoflorine iodide;Antifungal agent 39
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