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Aminopterin
CAS No. : 54-62-6
Biological Activity：Aminopterin (4-Aminofolic acid), the 4-amino derivative of folic acid, is a folic acid antagonist. Aminopterin catalyses the reduction of folic acid to tetrahydrofolic acid, and competitively inhibits dihydrofolate reductase (DHFR) with a Ki of 3.7 pM. Aminopterin has anticancer and immunosuppressive activity. Aminopterin is used in treatment of pediatric leukemia[2].
Research Area：Cancer|Inflammation/Immunology
Targets：Antifolate
Related Screening Libraries:Natural Product-like Compound Library;Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound Library Plus;Cell Cycle/DNA Damage Compound Library;Immunology/Inflammation Compound Library;Anti-Cancer Compound Library;Clinical Compound Library;Anti-Aging Compound Library;Drug Repurposing Compound Library;Anti-Blood Cancer Compound Library;Anti-Cancer Metabolism Compound Library;Rare Diseases Drug Library;Human Metabolite Library;
Related Small Molecules:Cycloguanil D6 Nitrate;FRα-IN-1;Edatrexate;TNP-351;Metoprine;LY309887;Tetroxoprim;LY 222306;Levomefolate calcium;Lometrexol hydrate;Trimetrexate trihydrochloride;Mirvetuximab;DHFR-IN-3;Folinic acid disodium;EC0489;Folinic acid calcium;DHFR-IN-2;EC0488;Levomefolate-13C5 calcium;Pelitrexol;LSN 3213128;Fanotaprim;Aditoprime;Trimetrexate glucuronate;Diaveridine
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