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Amifostine
CAS No. : 20537-88-6
Biological Activity：Amifostine (WR2721) is a broad-spectrum cytoprotective agent and a radioprotector. Amifostine selectively protects normal tissues from damage caused by radiation and chemotherapy. Amifostine is potent hypoxia-inducible factor-α1 (HIF-α1) and p53 inducer. Amifostine protects cells from damage by scavenging oxygen-derived free radicals. Amifostine reduces renal toxicity and has antiangiogenic action[2][3][4].
Research Area：Cancer
Targets：HIF/HIF Prolyl-Hydroxylase|MDM-2/p53
Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library Mini;Bioactive Compound Library Plus;Apoptosis Compound Library;Epigenetics Compound Library;Immunology/Inflammation Compound Library;Metabolism/Protease Compound Library;FDA-Approved Drug Library;Anti-Cancer Compound Library;Autophagy Compound Library;Anti-Aging Compound Library;Drug Repurposing Compound Library;Reprogramming Compound Library; Oxygen Sensing Compound Library;Ferroptosis Compound Library;Anti-COVID-19 Compound Library;NMPA-Approved Drug Library;Pyroptosis Compound Library;Glutamine Metabolism Compound Library;FDA Approved & Pharmacopeial Drug Library;Drug-Induced Liver Injury (DILI) Compound Library;Anti-Pancreatic Cancer Compound Library;Anti-Blood Cancer Compound Library;Anti-Cancer Metabolism Compound Library;Angiogenesis-Related Compound Library;Transcription Factor-Targeted Library;Rare Diseases Drug Library;Anti-Colorectal Cancer Compound Library ;Chemotherapy Drug Library;FDA-Approved Anticancer Drug Library;Human Metabolite Library;Anti-Prostate Cancer Compound Library;
Related Small Molecules:MDM2-p53-IN-15;TC-S 7009;Glucosamine-13C hydrochloride;MC-VC-PABC-SP 141;HIF1-IN-3;p53 and MDM2 proteins-interaction-inhibitor (racemic);Navtemadlin;Prolyl Hydroxylase inhibitor 1;Glucosamine-13C6,15N hydrochloride;HIF-PHD-IN-1;MD-224;Mutant p53 modulator-1;MDM2/4-p53-IN-2;MX69;p-nitro-Pifithrin-α;RG7112;AKBA;MMRi62;LW6;Anticancer agent 50;NSC59984;Pifithrin-β hydrobromide;Ivaltinostat formic;HIF-2α-IN-5;HIF-1/2α-IN-2;GEM-5;HIF-1/2α-IN-1;Tenovin-6
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