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AMG-47a
CAS No. : 882663-88-9
Biological Activity：AMG-47a is a potent and orally active lymphocyte-specific protein tyrosine kinase (Lck) inhibitor, with an IC50 of 0.2 nM. AMG-47a also inhibits VEGF2, p38α, Jak3 and MLR and IL-2 with IC50s of 1 nM, 3 nM, 72 nM, 30 nM and 21 nM, respectively. AMG-47a has anti-inflammatory activity.
Research Area：Inflammation/Immunology
Targets：JAK|p38 MAPK|VEGFR|Src
Related Screening Libraries:Bioactive Compound Library Plus;Epigenetics Compound Library;Immunology/Inflammation Compound Library;JAK/STAT Compound Library;Kinase Inhibitor Library;MAPK Compound Library;Protein Tyrosine Kinase Compound Library;Stem Cell Signaling Compound Library;Anti-Aging Compound Library;Differentiation Inducing Compound Library;Reprogramming Compound Library;Oxygen Sensing Compound Library;Pyroptosis Compound Library;Orally Active Compound Library;Anti-Breast Cancer Compound Library;Anti-Lung Cancer Compound Library;Anti-Pancreatic Cancer Compound Library;Anti-Blood Cancer Compound Library;Anti-Cancer Metabolism Compound Library;Neurodegenerative Disease-related Compound Library;Anti-Obesity Compound Library;Angiogenesis-Related Compound Library;Anti-Liver Cancer Compound Library ;Anti-Colorectal Cancer Compound Library ;Antidepressant Compound Library;Anti-Prostate Cancer Compound Library;Anti-Pulmonary Fibrosis Compound Library; Cancer Stem Cells Compound Library;
Related Small Molecules:AZ-3;(Z)-FeCP-oxindole;KB SRC 4;Tirbanibulin dihydrochloride;JAK3/BTK-IN-1;VEGFR-2-IN-24;BMS-690514;AT9283;Benzene hexabromide;Bafetinib;PROTAC VEGFR-2 degrader-2;(E/Z)-Zotiraciclib;p60c-src substrate II;Henatinib;SB-747651A dihydrochloride;Dehydrocorydaline;JAK-IN-10;Baricitinib-d3;SKF-86002 dihydrochloride;PI3K/VEGFR2-IN-1;JAK3-IN-6;Caffeic acid-pYEEIE TFA;PP2;Coumermycin A1
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