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AMD 3465 hexahydrobromide

CAS No. : 185991-07-5

Biological Activity：AMD 3465 hexahydrobromide (GENZ-644494 hexahydrobromide) is a potent antagonist of CXCR4, inhibits binding of 12G5 mAb and CXCL12^AF647 to CXCR4, with IC₅₀s of 0.75 nM and 18 nM in SupT1 cells; AMD 3465 also potently inhibits the replication of X4 HIV strains (IC₅₀: 1-10 nM), but has no effect on CCR5-using (R5) viruses.

Research Area：Infection|Endocrinology

Targets：CXCR|HIV

Related Screening Libraries:Bioactive Compound Library Plus;Anti-Infection Compound Library;GPCR/G Protein Compound Library;Immunology/Inflammation Compound Library;Antiviral Compound Library;Small Molecule Immuno-Oncology Compound Library;Macrocyclic Compound Library;Endocrinology Compound Library;Human Metabolite Library;Chemokine Compound Library;

Related Small Molecules:Nicotinamide N-oxide;HIV-1 TAT (48-60);Seletracetam lithium;HIV-IN-2;Triptonine B;FC131;Peritassine A;CXCR4 antagonist 2;Flavopiridol;AMG 487 (S-enantiomer);TAT (48-57);FGI-106 tetrahydrochloride;(Z)-9-Propenyladenine;Apabetalone;CXCR4 antagonist 6;Decanoyl-RVKR-CMK TFA;ONX-0914 TFA;Apelin-36(rat, mouse);Ulonivirine

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