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Alectinib
CAS No. : 1256580-46-7
Biological Activity：Alectinib (CH5424802) is a potent, selective, and orally available ALK inhibitor with an IC50 of 1.9 nM and a Kd value of 2.4 nM (in an ATP-competitive manner), and also inhibits ALK F1174L and ALK R1275Q with IC50s of 1 nM and 3.5 nM, respectively. Alectinib demonstrates effective central nervous system (CNS) penetration[2].
Research Area：Cancer
Targets：Anaplastic lymphoma kinase (ALK)
Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library Mini;Bioactive Compound Library Plus;Kinase Inhibitor Library;Protein Tyrosine Kinase Compound Library;FDA-Approved Drug Library;Anti-Cancer Compound Library;CNS-Penetrant Compound Library;Drug Repurposing Compound Library;Orally Active Compound Library;Chemical Probe Library;FDA Approved & Pharmacopeial Drug Library;Drug-Induced Liver Injury (DILI) Compound Library;Anti-Pancreatic Cancer Compound Library;Targeted Therapy Drug Library ;Targeted Diversity Library;Rare Diseases Drug Library;Children’s Drug Library;EMA-Approved Drug Library;FDA-Approved Anticancer Drug Library;Human Metabolite Library;
Related Small Molecules:ALK-IN-9;KRCA-0008;Alectinib-d8;MS4078;TL13-22;NVP-TAE 684;ALK5-IN-30;TL13-112;ALK-IN-22;ALK-IN-12;Entrectinib;ALK kinase inhibitor-1;WY-135;TL13-110;ALK inhibitor 1;Envonalkib;GSK1838705A;RIPK2-IN-1;CJ-2360;ALK-IN-1;ALK5-IN-29;X-376;ALK-IN-21;Repotrectinib;Lorlatinib;M4K2234;MS4077
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