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A-317491
CAS No. : 475205-49-3
Biological Activity：A-317491 is a potent, selective and non-nucleotide antagonist of P2X3 and P2X2/3 receptors, with Kis of 22, 22, 9, and 92 nM for hP2X3, rP2X3, hP2X2/3, and rP2X2/3, respectively. A-317491 is highly selective (IC50>10 μM) over other P2 receptors and other neurotransmitter receptors, ion channels, and enzymes. A-317491 reduces inflammatory and neuropathic pain by blocking P2X3 and P2X2/3 receptor-mediated calcium flux[2].
Research Area：Inflammation/Immunology|Neurological Disease
Targets：P2X Receptor
Related Screening Libraries:Bioactive Compound Library Plus;Immunology/Inflammation Compound Library;Membrane Transporter/Ion Channel Compound Library;Neurotransmitter Receptor Compound Library;
Related Small Molecules:Gefapixant citrate;JNJ-47965567;AF-353;Oxatomide;AZ10606120 dihydrochloride;Taspine;NF449 octasodium;A-804598;P2X receptor-1;Aurintricarboxylic acid;Minodronic acid;NF023 hexasodium;A 438079 hydrochloride;KN-62;Opiranserin;GW791343 dihydrochloride;5-BDBD;NF279;Lu AF27139;JNJ-55308942;PPNDS tetrasodium;8-Bromo-ATP;P2X3 antagonist 36;NF110;BAY-1797;Ro-51;P2X3 antagonist 37
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