5-(N,N-Hexamethylene)-amiloride

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5-(N,N-Hexamethylene)-amiloride

CAS No. : 1428-95-1

Biological Activity：5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) derives from an amiloride and is a potent Na+/H+ exchanger inhibitor, which decreases the intracellular pH (pHi) and induces apoptosis in leukemic cells. 5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) is also an inhibitor of the HIV-1 Vpu virus ion channel and inhibits mouse hepatitis virus (MHV) replication and human coronavirus 229E (HCoV229E) replication in cultured L929 cells with EC50s of 3.91 μM and 1.34 μM, respectively[2].

Research Area：Cancer|Infection

Targets：Sodium Channel|HIV|Apoptosis

Related Screening Libraries:Bioactive Compound Library Plus;Anti-Infection Compound Library;Apoptosis Compound Library;Membrane Transporter/Ion Channel Compound Library;Anti-Cancer Compound Library;Antiviral Compound Library;Neuroprotective Compound Library;Sodium Channel Blocker Library;Human Metabolite Library;

Related Small Molecules:Physalin A;Bomedemstat ditosylate;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;Lu AE98134;BJE6-106;Dinaciclib;HIV-1 TAT (48-60);Ecteinascidin 770;MDM2-p53-IN-15;Seletracetam lithium;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8;Topoisomerase I/II inhibitor 3;HIV-IN-2;Xevinapant;Mangiferin;Zandatrigine;Cambinol;Antioxidant agent-5

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