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20(S)-Hydroxycholesterol
CAS No. : 516-72-3
Biological Activity：20(S)-hydroxyCholesterol (20α-Hydroxycholesterol) is an allosteric activator of the oncoprotein smoothened (Smo) that activates the hedgehog (Hh) signaling pathway with an EC50 of 3 μM in a gene transcription reporter assay using NIH3T3 cells[2].
Research Area：Cancer
Targets：Smo|Endogenous Metabolite
Related Screening Libraries:Natural Product Library Plus;Bioactive Compound Library Plus;Metabolism/Protease Compound Library;Stem Cell Signaling Compound Library;Wnt/Hedgehog/Notch Compound Library;Natural Product Library;Anti-Cancer Compound Library;Human Endogenous Metabolite Compound Library;Anti-Aging Compound Library;Reprogramming Compound Library;Lipid Compound Library;Anti-Pancreatic Cancer Compound Library;Food-Sourced Compound Library ;Anti-Cancer Natural Product Library;Human Metabolite Library;
Related Small Molecules:D-α-Hydroxyglutaric acid disodium;Nicotinamide N-oxide;3-Hydroxyglutaric acid-d5;DPPC-d62;SDMA-d6;2-Mercaptobenzothiazole;N-Acetyl-L-glutamic acid-d5;(3R,5S)-3-Hydroxy Cotinine-d3;Biliverdin hydrochloride;D-Glucose-13C,d1-3;2,3-Diaminopropionic acid hydrochloride;Docosanoic acid-d3;Choline-d6 chloride;Pregnenolone monosulfate sodium;25-Hydroxycholesterol-d6;Pyrroloquinoline quinone;Roridin L2;NAPQI;Imidazole;Adipokinetic hormone I (Locusta migratoria)
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