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(1E)-CFI-400437 dihydrochloride
CAS No. : 1247000-76-5
Biological Activity：(1E)-CFI-400437 dihydrochloride is a potent PLK4 (IC50= 0.6 nM) inhibitor and selective against other members of the PLK family (>10 μM). (1E)-CFI-400437 dihydrochloride inhibits Aurora A, Aurora B, KDR and FLT-3 with IC50s of 0.37, 0.21, 0.48, and 0.18 μM, respectively. Antiproliferative activity.
Research Area：Cancer
Targets：Polo-like Kinase (PLK)
Related Screening Libraries:Natural Product-like Compound Library;Bioactive Compound Library Plus;Cell Cycle/DNA Damage Compound Library;Kinase Inhibitor Library;Anti-Cancer Compound Library;Anti-Aging Compound Library;
Related Small Molecules:TAK-960;Rigosertib sodium;Centrinone;HMN-176;Poloxin;PLK1-IN-2;PLK1-IN-4;MLN0905;TC-S 7005;PLK4-IN-3;SBE13 Hydrochloride;CFI-400437;Plogosertib;Volasertib;3MB-PP1;Wortmannin;PLK1/BRD4-IN-1;Poloxime;Poloppin;Cyclapolin 9;ON1231320;BI 2536
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