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β-Hydroxyisovalerylshikonin
CAS No. : 7415-78-3
Biological Activity：Beta-hydroxyisovalerylshikonin is a natural product isolated from Lithospermum erythrorhizon, acts as a potent inhibitor of protein tyrosine kinases (PTK), with IC50s of 0.7μM and 1μM for EGFR and v-Src receptor, respectively. Beta-hydroxyisovalerylshikonin is effective against a wide variety of tumor cell lines, and most efficiently induces cell-death in NCI-H522 and DMS114 cells.
Research Area：Cancer
Targets：EGFR|Src
Related Screening Libraries:Natural Product Library Plus;Bioactive Compound Library Plus;Immunology/Inflammation Compound Library;JAK/STAT Compound Library;Kinase Inhibitor Library;Protein Tyrosine Kinase Compound Library;Natural Product Library;Anti-Cancer Compound Library;Differentiation Inducing Compound Library;Reprogramming Compound Library;Phenols Library;Traditional Chinese Medicine Active Compound Library;Anti-Hepatitis C Virus Compound Library;Anti-Lung Cancer Compound Library;Anti-Pancreatic Cancer Compound Library;Anti-Obesity Compound Library;Angiogenesis-Related Compound Library;Anti-Liver Cancer Compound Library ;Anti-Colorectal Cancer Compound Library ;Anti-Cancer Natural Product Library;Anti-inflammatory Traditional Chinese Medicine Active Compound Library;Plant-Sourced Natural Product Library;Anti-Prostate Cancer Compound Library;Anti-Pulmonary Fibrosis Compound Library;Cancer Stem Cells Compound Library;
Related Small Molecules:KB SRC 4;Tirbanibulin dihydrochloride;NSC81111;pp60 (v-SRC) Autophosphorylation Site, Phosphorylated;BMS-690514;Bafetinib;Osimertinib-13C,d3;p60c-src substrate II;EGFR-IN-5;FGFR2-IN-3;Caffeic acid-pYEEIE TFA;Genistein;Epertinib hydrochloride;PP2;PP58;UNC-CA359;Osimertinib mesylate;AV-412 free base;Nelipepimut-S;Falnidamol;HER2-IN-6;ENMD-2076 Tartrate;CH6953755;PROTAC EGFR degrader 7;CHMFL-EGFR-202
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