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WDR5-IN-1

CAS No. : 2408842-51-1

Biological Activity：WDR5-IN-1 is a potent and selective WD repeat domain 5 (WDR5) inhibitor, with a K_d of <0.02 nM. WDR5-IN-1 inhibits MLL1 histone methyltransferase (HMT) activity with an IC₅₀ of 2.2 nM. WDR5-IN-1 diminishes MYC recruitment at WDR5-displaced genes and exhibits potent anti-proliferative effects in CHP-134 (neuroblastoma) and Ramos (Burkitt’s lymphoma) lines.

Research Area：Cancer

Targets：Histone Methyltransferase|Apoptosis

Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Epigenetics Compound Library;Histone Modification Research Compound Library;Anti-Cancer Compound Library;Reprogramming Compound Library;Anti-Blood Cancer Compound Library;

Related Small Molecules:Physalin A;Bomedemstat ditosylate;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;EEDi-5285;BJE6-106;Dinaciclib;Ecteinascidin 770;MDM2-p53-IN-15;EZH2-IN-2;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8;Topoisomerase I/II inhibitor 3;Xevinapant;Mangiferin;Cambinol;Antioxidant agent-5;Apoptosis inducer 9;BIX-01294;Bafetinib

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