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Ursodeoxycholic acid
CAS No. : 128-13-2
Biological Activity：Ursodeoxycholic acid (Ursodeoxycholate) is a secondary bile acid issued from the transformation of (cheno)deoxycholic acid by intestinal bacteria, acting as a key regulator of the intestinal barrier integrity and essential for lipid metabolism. Ursodeoxycholic acid acts as signaling molecule, exerting its effects by interacting with bile acid activated receptors, including G-protein coupled bile acid receptor 5 (TGR5, GPCR19) and the farnesoid X receptor (FXR). Ursodeoxycholic acid can be used for the research of a variety of hepatic and gastrointestinal diseases. Ursodeoxycholic acid also reduces ACE2 expression and is beneficial for reducing SARS-CoV-2 infection. Orally active[2][3][4].
Research Area：Cancer|Infection|Metabolic Disease
Targets：Angiotensin-converting Enzyme (ACE)|FXR|Endogenous Metabolite|G protein-coupled Bile Acid Receptor 1
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