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Tolcapone D7

Biological Activity：Tolcapone D7 (Ro 40-7592 D7) is a deuterium labeled Tolcapone. Tolcapone is a selective, potent and orally active COMT inhibitor. Tolcapone is also a potent inhibitor of α-syn and Aβ42 oligomerization and fibrillogenesis and protect against extracellular toxicity induced by the aggregation of both proteins in PC12 cells^[2].

Research Area：Neurological Disease

Targets：COMT|Amyloid-β

Related Small Molecules:β-Amyloid (13-27);Nebicapone;Saikosaponin C;β-Amyloid (1-42), (rat/mouse) (TFA);Nitecapone;β-Amyloid (12-28) (TFA);BuChE-IN-5;Ginsenoside Rg1;MDR-1339;β-Amyloid (11-22);20(S)-Ginsenoside Rg3;β-Amyloid (31-35);Aβ-IN-1;Qingyangshengenin B;JNJ-40418677;HDAC6-IN-6;β-Amyloid (1-37) (human);CGP52411;Astrophloxine;γ-Secretase modulator 12;δ-Secretase inhibitor 11;BuChE-IN-2;FPS-ZM1;BChE-IN-8;4-(6-Bromo-2-benzothiazolyl)benzenamine;Timosaponin BII

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Structurally and synthetically diverse biologically active compounds；

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