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TL12-186

CAS No. : 2250025-88-6

Biological Activity：TL12-186 is a Cereblon-dependent multi-kinase PROTAC degrader. Multi-kinases include CDK, BTK, FLT3, Aurora kinases, TEC, ULK, ITK, et al. TL12-186 inhibits CDK2/cyclin A (IC₅₀=73 nM) and CDK9/cyclin T1 (IC₅₀=55 nM).

Research Area：Cancer

Targets：CDK|PROTACs

Related Screening Libraries:Bioactive Compound Library Plus;Cell Cycle/DNA Damage Compound Library;Kinase Inhibitor Library;Anti-Cancer Compound Library;Anti-Aging Compound Library;Anti-Breast Cancer Compound Library;Anti-Blood Cancer Compound Library;Cancer Stem Cells Compound Library;

Related Small Molecules:PROTAC Sirt2 Degrader-1;DB0614;Dinaciclib;SNS-032;CC-671;PROTAC VEGFR-2 degrader-2;(E/Z)-Zotiraciclib;dTAGV-1-NEG;CCT367766 formic;CDK1-IN-4;CCT-251921;BS-181;Samuraciclib hydrochloride hydrate;T025;HDAC6 degrader-1;Flavopiridol;CDK8-IN-3;PROTAC Axl Degrader 2;PhosTAC7;CDK9-IN-12;MS98;FLT3/CDK4-IN-1;GFB-12811;GSK 3 Inhibitor IX;JPS014;Eciruciclib;PROTAC PARP1 degrader;MD-224;CDK-IN-6

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