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Tioxolone
CAS No. : 4991-65-5
Biological Activity：Tioxolone, a metalloenzyme carbonic anhydrase I inhibitor, is an anti-acne preparation.
Target: Carbonic Anhydrase
Tioxolone is a metalloenzyme carbonic anhydrase I inhibitor with a Ki of 91 nM. Tioxolone lacks sulfonamide, sulfamate, or hydroxamate functional groups that are typically found in therapeutic carbonic anhydrase (CA) inhibitors, such as acetazolamide. Tioxolone is proposed to be a prodrug inhibitor that is cleaved via a CA II zinc-hydroxide mechanism known to catalyze the hydrolysis of esters. When tioxolone binds in the active site of CA II, it is cleaved and forms 4-mercaptobenzene-1,3-diol via the intermediate S-(2,4-thiophenyl) hydrogen thiocarbonate. The esterase cleavage product binds to the zinc active site via the thiol group and is therefore the active CA inhibitor, while the intermediate is located at the rim of the active-site cavity. From Wikipedia.
Research Area：Metabolic Disease
Targets：Carbonic Anhydrase
Related Screening Libraries:Bioactive Compound Library Plus;Metabolism/Protease Compound Library;FDA Approved & Pharmacopeial Drug Library;
Related Small Molecules:Enpp/Carbonic anhydrase-IN-1;hCAIX-IN-8;Phenylsulfamide;Benzolamide;(E)-Dehydrodiconiferyl alcohol;hCAIX/XII-IN-1;CAXII-IN-1;hCAIX/XII-IN-2;hCAIX-IN-12;Girentuximab;hCAII-IN-2;hCAI/II-IN-1;hCAI/II-IN-4;Dichlorphenamide;hCAIX-IN-16;hCAII-IN-1;Sultiame;hCAII-IN-3;Carbonic anhydrase inhibitor 6;hCAXII-IN-4;hCAIX-IN-10;U-104;Carbonic anhydrase inhibitor 4;EMAC10101d
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