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TAS05567
CAS No. : 1429038-15-2
Biological Activity：TAS05567 is a potent, highly selective, ATP-competitive and orally active Syk inhibitor with an IC50 of 0.37 nM. In a panel of 192 kinases, TAS05567 only shows >70% inhibition of Syk and 4 other kinases (FLT3, JAK2, KDR and RET with IC50s of 10 nM, 4.8 nM, 600 nM and 29 nM, respectively). TAS05567 can be used for humoral immune-mediated inflammatory conditions such as autoimmune and allergic diseases.
Research Area：Inflammation/Immunology
Targets：RET|Syk
Related Small Molecules:RET-IN-18;Lanraplenib monosuccinate;Zeteletinib;RET-IN-5;GSK3179106;OXSI-2;Pyrazoloadenine;trans-Pralsetinib;PF 477736;SYK/JAK-IN-1;BT-13;PRT062607 Hydrochloride;MNS;TAK-659 hydrochloride;RET-IN-8;Syk Inhibitor II dihydrochloride dihydrate;AD80;JNJ-38158471;Fostamatinib-d9;Amuvatinib hydrochloride;RET-IN-11;TRK II-IN-1;RET-IN-10;R406 free base;RET-IN-17;Fostamatinib Disodium
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