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SIAIS164018
CAS No. : 2353492-68-7
Biological Activity：SIAIS164018 is a PROTAC-based ALK and EGFR degrader, which is designed from Brigatinib (HY-12857), with IC50 value of 2.5 nM and 6.6 nM for ALK and ALK G1202R, respectively. SIAIS164018 strongly inhibits cancer cells migration and invasion, causes G1 cell cycle arrest and induces apoptosis. SIAIS164018 exhibits better property than Brigatinib.
Research Area：Cancer
Targets：EGFR|Anaplastic lymphoma kinase (ALK)|PROTACs|Apoptosis
Related Small Molecules:Physalin A;Bomedemstat ditosylate;PROTAC Sirt2 Degrader-1;DB0614;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;ALK-IN-9;NSC81111;BJE6-106;Dinaciclib;pp60 (v-SRC) Autophosphorylation Site, Phosphorylated;Ecteinascidin 770;MDM2-p53-IN-15;BMS-690514;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8;Topoisomerase I/II inhibitor 3;Xevinapant;Mangiferin;Cambinol
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
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