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SCH-42354
CAS No. : 144505-58-8
Biological Activity：SCH-42354 is a potent, orally active neutral endopeptidase (NEP) inhibitor, is the pharmacologically active form of the prodrug SCH-42495. SCH-42354 inhibits the hydrolysis of NEP to enhance the activity of atrial natriuretic peptide (ANP). SCH-42354 inhibits hydrolysis of leu-enkephalin and ANF with IC50 values of 8.3 nM and 10.0 nM, respectively. SCH-42354 has antihypertensive activity[2].
Research Area：Cardiovascular Disease
Targets：Neprilysin
Related Small Molecules:TD-0212;Thiorphan;Phosphoramidon Disodium;Sacubitril-13C4 hemicalcium salt;Sacubitrilat;SCH 42495 racemate;NEP-IN-2;Thiorphan-d5;Racecadotril-d5;Racecadotril;Sacubitril hemicalcium salt;NEP-In-1;Candoxatril;Sampatrilat;SQ28603;Opiorphin
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