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SB-218078

CAS No. : 135897-06-2

Biological Activity：SB-218078 is a potent, selective, ATP-competitive and cell-permeable checkpoint kinase 1 (Chk1) inhibitor that inhibits Chk1 phosphorylation of cdc25C with an IC₅₀ of 15 nM. SB-218078 is less potently inhibits Cdc2 (IC₅₀ of 250 nM) and PKC (IC₅₀ of 1000 nM). SB-218078 causes apoptosis by DNA damage and cell cycle arrest^[2][3].

Research Area：Cancer

Targets：CDK|PKC|Apoptosis|Checkpoint Kinase (Chk)

Related Small Molecules:Physalin A;Bomedemstat ditosylate;DB0614;Enpp/Carbonic anhydrase-IN-1;[Ala107]MBP(104-118) TFA;GK563;Calpeptin;Lobetyolin;BJE6-106;Dinaciclib;Ecteinascidin 770;MDM2-p53-IN-15;Myelin Basic Protein;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8;Topoisomerase I/II inhibitor 3;CC-671;Xevinapant;Mangiferin;Cambinol;PKC-iota inhibitor 1

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