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(Rac)-BRD0705
CAS No. : 1597440-03-3
Biological Activity：(Rac)-BRD0705 is a less active racemate of BRD0705. BRD0705 is a potent, paralog selective and orally active GSK3α inhibitor with an IC50 of 66 nM and a Kd of 4.8 μM. BRD0705 displays increased selectivity for GSK3α (8-fold) versus GSK3β (IC50 of 515 nM). BRD0705 can be used for acute myeloid leukemia (AML)[2].
Research Area：Cancer
Targets：GSK-3
Related Small Molecules:TCS2002;AR-A014418;GSK 3 Inhibitor IX;MeBIO;Cromolyn-d5 sodium;GS87;ZDWX-25;ARN25068;PfGSK3/PfPK6-IN-2;RGB-286638;Laduviglusib (GMP);GSK3 Substrate, α, β subunit;DIF-3;Bikinin;A 1070722;Indirubin-3′-monoxime;Indirubin-5-sulfonate;Aloisine RP106;GNF4877;Indirubin-3′-monoxime-5-sulphonic acid;ABC1183;GSK-3β inhibitor 10;Cromolyn sodium;AZD1080;TCS 21311;KY19382;CHIR-98014;BRD0209;SB 415286
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