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R59949

CAS No. : 120166-69-0

Biological Activity：R59949 is a pan diacylglycerol kinase (DGK) inhibitor with an IC₅₀ of 300 nM. R59949 strongly inhibits the activity of type I DGK α and γ and moderately attenuates the activity of type II DGK θ and κ. R59949 activates protein kinase C (PKC) by enhancing the levels of the endogenous ligand diacyl glycerol^[2]^[3].

Research Area：Cancer

Targets：PKC

Related Screening Libraries:Bioactive Compound Library Plus;Epigenetics Compound Library;Kinase Inhibitor Library;TGF-beta/Smad Compound Library;Anti-Cancer Compound Library;Oxygen Sensing Compound Library;Cytoskeleton Compound Library;Coagulation and Anti-coagulation Compound Library;

Related Small Molecules:[Ala107]MBP(104-118) TFA;BJE6-106;Myelin Basic Protein;Staurosporine;PKC-iota inhibitor 1;Hypericin;Malantide;PKCiota-IN-2 formic;PF-4950834;C8 Dihydroceramide;SC-9;DL-erythro-Dihydrosphingosine;Safingol;ZIP;Psychosine-d5;TPPB;Enzastaurin;Protein Kinase C (19-31);Protein kinase inhibitor H-7 dihydrochloride;Teleocidin A1;Ro 31-8220;[Ser25] Protein Kinase C (19-31);CGP60474

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