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R18
CAS No. : 211364-78-2
Biological Activity：R18 is a peptide antagonists of 14-3-3, with a KD of 70-90 nM. R18 efficiently blocks the binding of 14-3-3 to the kinase Raf-1, a physiological ligand of 14-3-3, and effectively abolished the protective role of 14-3-3 against phosphatase-induced inactivation of Raf-1.
Research Area：Cancer
Targets：Raf
Related Small Molecules:Avutometinib;AZ 628;Everafenib;L-779450;Raf inhibitor 1;PLX-4720;RRD-251;B-Raf IN 8;TAK-632;Encorafenib;RAF mutant-IN-1;AD80;CCT241161;PLX7904;RAF-IN-1;EGFR/BRAFV600E-IN-1;MCP110;GDC-0879;B-Raf IN 1;Rineterkib
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