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R-268712
CAS No. : 879487-87-3
Biological Activity：R-268712 is an orally active and selective ALK-5 inhibitor, with an IC50 of 2.5 nM. R-268712 inhibits the phosphorylation of Smad3 in a dose-dependent manner with an IC50 of 10.4 nM. R-268712 suppresses glomerulonephritis as well as glomerulosclerosis by inhibiting TGF-β signaling, which can be used in studies of renal fibrosis and cancer[2].
Research Area：Cancer|Inflammation/Immunology|Cardiovascular Disease
Targets：TGF-beta/Smad|Anaplastic lymphoma kinase (ALK)|TGF-β Receptor
Related Screening Libraries:Bioactive Compound Library Plus;Immunology/Inflammation Compound Library;Kinase Inhibitor Library;Protein Tyrosine Kinase Compound Library;Stem Cell Signaling Compound Library;TGF-beta/Smad Compound Library;Wnt/Hedgehog/Notch Compound Library;Anti-Cancer Compound Library;Anti-Aging Compound Library;Reprogramming Compound Library;Anti-Cardiovascular Disease Compound Library;Orally Active Compound Library;Anti-Pancreatic Cancer Compound Library;Anti-Obesity Compound Library;Angiogenesis-Related Compound Library;Transcription Factor-Targeted Library;Anti-Colorectal Cancer Compound Library ;Anti-Prostate Cancer Compound Library;Anti-Pulmonary Fibrosis Compound Library;Osteogenesis Compound Library;Cancer Stem Cells Compound Library;
Related Small Molecules:ALK-IN-9;TGFβ-IN-2;ML347;LDN193189 (GMP);TGFβRI-IN-4;KRCA-0008;ALK5-IN-6;TGFβ-IN-1;Alectinib-d8;p-nitro-Pifithrin-α;MS4078;TL13-22;NVP-TAE 684;SRI-011381;Ponsegromab;Isoviolanthin;Chromenone 1;ALK5-IN-30;TL13-112;OD36;ALK-IN-22;ALK5-IN-32;SB-505124 hydrochloride;Alectinib;K02288;ALK-IN-12;Asiaticoside;Halofuginone hydrobromide
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