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Pregnenolone

CAS No. : 145-13-1

Biological Activity：Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication^[2]. Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels^[3].

Research Area：Neurological Disease

Targets：Autophagy|TRP Channel|Endogenous Metabolite|Cannabinoid Receptor

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