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PIN1 inhibitor API-1
CAS No. : 680622-70-2
Biological Activity：PIN1 inhibitor API-1 is a specific Pin1 (peptidyl-prolyl cis–trans isomerase NIMA-interacting 1) inhibitor (API-1) with an IC50 of 72.3 nM. PIN1 inhibitor API-1 directly and specifically binds to the Pin1 peptidyl-prolyl isomerase (PPIase) domain and potently inhibits Pin1 cis–trans isomerizing activity. PIN1 inhibitor API-1 retains the active conformation of pXPO5 and restores the ability of pXPO5 to transport pre-miRNAs from nucleus to cytoplasm, thus up-regulating the anticancer miRNA biogenesis to suppress both in vitro and in vivo hepatocellular carcinoma development.
Research Area：Cancer
Targets：MicroRNA
Related Screening Libraries:Bioactive Compound Library Plus;Epigenetics Compound Library;Anti-Cancer Compound Library;Transcription Factor-Targeted Library;Anti-Liver Cancer Compound Library ;Protein-protein Interaction Inhibitor Library;
Related Small Molecules:(R)-Camptothecin-d5;Targaprimir-96 TFA;Lin28-let-7a antagonist 1;Camptothecin;Miravirsen;microRNA-21-IN-2;MIR96-IN-1;Gypenoside LI;Aurintricarboxylic acid;PIN1 inhibitor 2;LIN28 inhibitor LI71;Pseudoprotodioscin;Cl-amidine TFA;SID 3712249;RJW100;RG-101;TGP-377/421;Camptothecin-d5;Lademirsen;Targapremir-210;microRNA-21-IN-1
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