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Piericidin A

CAS No. : 2738-64-9

Biological Activity：Piericidin A (AR-054) is a natural mitochondrial NADH-ubiquinone oxidoreductase (complex I) inhibitor. Piericidin A is a potent neurotoxin and inhibits mitochondrial respiration by disrupting the electron transport system through its action on NADH-ubiquinone reductase. Piericidin A is also a potential quorum-sensing inhibitor that suppresses the expression of the virulence genes of Erwinia carotovora subsp. atroseptica (Eca). Piericidin A is an ADC cytotoxin and has anti-bacterial, anticancer, insecticidal activity^[2]^[2].

Research Area：Cancer|Infection|Neurological Disease

Targets：ADC Cytotoxin|Bacterial|Antibiotic|Mitochondrial Metabolism

Related Small Molecules:Sandramycin;LLO (91-99);Gepotidacin;Oritavancin;Monascorubrin;Azlocillin sodium salt;Herbimycin A;Antibacterial agent 45;Leucomycin;Isouvaretin;Antibacterial agent 99;Vidarabine monohydrate;Nafcillin;Antitubercular agent-28;Ochromycinone;Staurosporine;Nucleocidin;(±)-Leucine-13C-1;Ciclopirox-d11;Ciclopirox olamine;Clotrimazole-d5;SQ109;(R)-Camptothecin-d5

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