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PF-04577806
CAS No. : 1072100-81-2
Biological Activity：PF-04577806 is a potent, selective and ATP competitive PKC inhibitor. PF-04577806 shows potent inhibitory activity towards PKCα, PKCβI, PKCβII, PKCγ, and PKCθ with IC50s of 2.4 nM, 8.1 nM, 6.9 nM, 45.9 nM, and 29.5 nM, respectively. PF-04577806 can reverse retinal vascular leakage in diabetic rats.
Research Area：Metabolic Disease
Targets：SHP2|PKC
Related Small Molecules:[Ala107]MBP(104-118) TFA;BJE6-106;Myelin Basic Protein;Staurosporine;PKC-iota inhibitor 1;Hypericin;Malantide;PKCiota-IN-2 formic;SHP504;SHP099 hydrochloride;PF-4950834;C8 Dihydroceramide;RMC-3943;SC-9;DL-erythro-Dihydrosphingosine;Safingol;ZIP;Psychosine-d5;TPPB;Enzastaurin;SHP394;Protein Kinase C (19-31);CD31 TFA
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