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Pacritinib

CAS No. : 937272-79-2

Biological Activity：Pacritinib (SB1518) is a potent inhibitor of both wild-type JAK2 (IC₅₀=23 nM) and JAK2^V617F mutant (IC₅₀=19 nM). Pacritinib also inhibits FLT3 (IC₅₀=22 nM) and its mutant FLT3^D835Y (IC₅₀=6 nM).

Research Area：Cancer

Targets：JAK|FLT3

Related Screening Libraries:Drug Repurposing Compound Library Plus;FDA-Approved Drug Library Plus;FDA-Approved Drug Library Mini;Bioactive Compound Library Plus;Epigenetics Compound Library;Immunology/Inflammation Compound Library;JAK/STAT Compound Library;Kinase Inhibitor Library;Protein Tyrosine Kinase Compound Library;Stem Cell Signaling Compound Library;FDA-Approved Drug Library;Anti-Cancer Compound Library;Anti-Aging Compound Library;Drug Repurposing Compound Library;Differentiation Inducing Compound Library;Reprogramming Compound Library;Macrocyclic Compound Library;FDA Approved & Pharmacopeial Drug Library;Anti-Breast Cancer Compound Library;Anti-Lung Cancer Compound Library;Anti-Pancreatic Cancer Compound Library;Anti-Blood Cancer Compound Library;Anti-Obesity Compound Library;Anti-Liver Cancer Compound Library ;Rare Diseases Drug Library;FDA-Approved Anticancer Drug Library;Anti-Prostate Cancer Compound Library;Cancer Stem Cells Compound Library;

Related Small Molecules:AZ-3;JAK3/BTK-IN-1;AT9283;Benzene hexabromide;(E/Z)-Zotiraciclib;JAK-IN-10;Baricitinib-d3;Crotonoside;JAK3-IN-6;FLT3-IN-13;PDGFRα/FLT3-ITD-IN-2;FLT3/CDK4-IN-1;Coumermycin A1;Deucravacitinib;Momelotinib-3,3,5,5-d4;SJ10542;HP1142;ENMD-2076 Tartrate;Delgocitinib;ATH686;AZD2932;Upadacitinib;α7 nAchR-JAK2-STAT3 agonist 1;Filgotinib-d4;AKN-028 acetate;AZD-1480

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