For research use only. We do not sell to patients.
Orexin 2 Receptor Agonist
CAS No. : 1796565-52-0
Biological Activity：Orexin 2 Receptor Agonist is a potent (EC50 on OX2R is 23 nM) and OX2R-selective (OX1R/OX2R EC50 ratio is 70) agonist.
IC50 value: 23 nM (EC50)
Target: Orexin 2 Receptor
Orexin 2 Receptor Agonist shows not only potent
activity but also high selectivity for OX2R over OX1R. In CHO cells overexpressing hOX1R and HEK-293 cells overexpressing hOX2R, compound 26 displaced [125I]orexin-A in a concentration dependent manner: 26 bound to hOX2R and hOX1R with Ki of 0.14 and 0.77 μM, respectively.[1]
Research Area：Neurological Disease|Endocrinology
Targets：Orexin Receptor (OX Receptor)
Related Screening Libraries:Bioactive Compound Library Plus;GPCR/G Protein Compound Library;Neuronal Signaling Compound Library;Endocrinology Compound Library;
Related Small Molecules:MK-3697;JNJ-54717793;TCS-OX2-29;IPSU;Seltorexant hydrochloride;Orexin B, rat, mouse;SB-649868;Orexin A (human, rat, mouse) (acetate);SB-408124 Hydrochloride;OX2R-IN-1;EMPA;Orexin B, human;SB-334867 free base;MK-1064;Almorexant-13C,d3;YNT-185 dihydrochloride;[Ala11,D-Leu15]-Orexin B(human);Suntinorexton;Almorexant;SB-674042;Filorexant;Orexin receptor antagonist 4;OXA(17-33) TFA;Lemborexant;Danavorexton
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
About Us:
- MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use；
- Structurally and synthetically diverse biologically active compounds；
- roduct quality is the key to our success and we take pride in offering only the highest-grade products.；
- We provide HNMR, LC-MS, HPLC, stability testing and activity assays of our products to clients.；
- Product identity, quality, purity and activity are assured by our robust quality control programs and procedures.；
- Customized order volume ranging from milligrams to kilograms scale；
Structurally and synthetically diverse biologically active compounds；
We provide customer-oriented services. To explore more, please contact us at [email protected]. Our team will gladly assist you.
