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NSC689857

CAS No. : 241127-79-7

Biological Activity：NSC689857 is a potent EGFR and SCF^SKP2 inhibitor with an IC₅₀ value of 36 μM for Skp2-Cks1. NSC689857 can inhibit p27 ubiquitylation (IC₅₀=30 μM). NSC689857 has varied activity across cancer types, with more activity against leukemia cell lines than others^[2].

Research Area：Cancer

Targets：EGFR|E1/E2/E3 Enzyme

Related Small Molecules:NSC81111;UBE2T/FANCL-IN-1;pp60 (v-SRC) Autophosphorylation Site, Phosphorylated;BMS-690514;Osimertinib-13C,d3;EGFR-IN-5;FGFR2-IN-3;p53 and MDM2 proteins-interaction-inhibitor (racemic);Navtemadlin;Genistein;Epertinib hydrochloride;UNC-CA359;MD-224;Osimertinib mesylate;AV-412 free base;Nelipepimut-S;DI-1859;Falnidamol;HER2-IN-6;MX69;PROTAC EGFR degrader 7;RG7112;CHMFL-EGFR-202;Avitinib;Naquotinib

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