NNC 55-0396

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NNC 55-0396

CAS No. : 357400-13-6

Biological Activity:NNC 55-0396, Mibefradil derivative, is a highly selective T-type calcium channel blocker; displays IC50 values of 6.8 and > 100 μM for inhibition of Cav3.1 T-type channels and HVA currents respectively in INS-1 cells.
IC50 value: 6.8 nM
Target: Cav3.1 T-type channel
NNC 55-0396 can be an essential tool in preventing human ovarian cancer cell proliferation as a result of its ability to inhibit the function of T-type Ca2+ channels. It is believed that NNC 55-0396 may functions by dissolving in or passing through the plasma membrane of cells.

Research Area:Cardiovascular Disease

Targets:Calcium Channel

Related Screening Libraries:Bioactive Compound Library Plus;Membrane Transporter/Ion Channel Compound Library;Neuronal Signaling Compound Library;Anti-Cardiovascular Disease Compound Library;Neuroprotective Compound Library;Calcium Channel Blocker Library;

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