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nAChR agonist 1
CAS No. : 1394371-75-5
Biological Activity：nAChR agonist 1 is a potent, brain-permeable, and orally efficacious positive allosteric modulator of α7 nicotinic acetylcholine receptor (α7 nAChR). nAChR agonist 1 has the EC50 of 0.32 µM in a Ca2+ mobilization assay (PNU-282987-induced, FLIPR based) in human IMR-32 neuroblastoma cells that endogenously express α7 nAChR. nAChR agonist 1 can be develpoped for the treatment of Alzheimer’s disease.
Research Area：Neurological Disease
Targets：nAChR
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Related Small Molecules:Spinosad;Pyrantel;NS 9283;Myosmine-d4;Benzethonium chloride;Dihydro-β-erythroidine;A-867744;Catestatin;Asoxime dichloride;α7 nAchR-JAK2-STAT3 agonist 1;AR-R17779 hydrochloride;Mecamylamine hydrochloride;Tropisetron;Zolunicant;S16961;NS3861;(±)-Anatoxin A fumarate;Oxantel;PHA-543613 dihydrochloride;(S)-Dinotefuran;Nelonicline citrate;Coclaurine;Cytisinicline;NS 1738;Asoxime-d4 dichloride;(R)-(+)-Anatabine;nAChR modulator-1;BNC210
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