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N-Desmethyl-Apalutamide
CAS No. : 1332391-11-3
Biological Activity：N-Desmethyl Apalutamide is an active metabolite of Apalutamide. N-Desmethyl Apalutamide is a less potent antagonist of the androgen receptor and is responsible for one-third of the activity of Apalutamide. The formation of N-Desmethyl Apalutamide mediated predominantly by CYP2C8 and CYP3A4. N-Desmethyl Apalutamide is moderate to strong CYP3A4 and CYP2B6 inducer and has an excellent plasma-proteins bound concentration[2][3].
Research Area：Cancer
Targets：Androgen Receptor|Cytochrome P450
Related Screening Libraries:Bioactive Compound Library Plus;
Related Small Molecules:VPC-14449;SR9186;AMG-208;CYP1B1-IN-1;CYP2C9/CYP2C19-IN-1;AC-262536;Hypericin;Galeterone;Ranitidine;GTx-007;Bergapten;Ginsenoside Rd;AS1810722;Linuron-d6;MI-136;Isoglycycoumarin;Polygalaxanthone III;Phenyltoloxamine;Ezutromid;Seviteronel;β-Apo-8′-carotenal;Diosmetin-d3;EDP-305
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