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MS31 trihydrochloride
Biological Activity：MS31 trihydrochloride is a potent, highly affinity and selective fragment-like methyllysine reader protein spindlin 1 (SPIN1) inhibitor. MS31 trihydrochloride potently inhibits the interactions between SPIN1 and H3K4me3 (IC50=77 nM, AlphaLISA; 243 nM, FP). MS31 trihydrochloride selectively binds Tudor domain II of SPIN1 (Kd=91 nM). MS31 trihydrochloride potently inhibits binding of trimethyllysine-containing peptides to SPIN1, and is not toxic to nontumorigenic cells.
Research Area：Cancer
Targets：Epigenetic Reader Domain
Related Screening Libraries:Natural Product-like Compound Library;Bioactive Compound Library Plus;Epigenetics Compound Library;Histone Modification Research Compound Library;Anti-Cancer Compound Library;Reprogramming Compound Library;Anti-Blood Cancer Compound Library;Transcription Factor-Targeted Library;Targeted Diversity Library;
Related Small Molecules:RVX-297;BRD4 Inhibitor-19;UNC6349 (Ket2);Curcumin;GSK6853;GSK4028;SR-0813;Inobrodib;Apabetalone;OF-1;I-CBP112;A-485;PLX51107;FKBP12 PROTAC dTAG-7;I-BET151;GSK040;BRM/BRG1 ATP Inhibitor-4;PBRM1-BD2-IN-5;MI-136;IACS-9571;SF2523;L-Moses dihydrochloride;KB02-JQ1;GSK620;INCB-057643;Bromodomain IN-1;QCA570;BRM/BRG1 ATP Inhibitor-1;Ziftomenib
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