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MS143

CAS No. : 2376137-41-4

Biological Activity：MS143 is a potent AKT degrader (DC₅₀=46 nM and GI₅₀=0.8 µM in PC3 cells). MS143 induces rapid and robust AKT degradation in a concentration- and time-dependent manner via hijacking the ubiquitin-proteasome system. MS143 can suppress cancer cell growth.

Research Area：Cancer

Targets：Akt

Related Small Molecules:Akt/NF-κB/JNK-IN-1;Cyclovirobuxine D;AKTide-2T;Sennidin A;MS98;PP2A Cancerous-IN-1;1,3-Dicaffeoylquinic acid;Artemisiane E;Artemisinin-d3;AS1949490;PI3K-IN-29;TD52 dihydrochloride;LM22B-10;AT13148;Pachymic acid;Glaucocalyxin A;PI3K/AKT-IN-2;INY-03-041;N-Oleoyl glycine;Triciribine;CCT128930;Chromeceptin;YS-49;AKT-IN-12;Licoricidin;A-443654;PI3K/AKT-IN-1;AKT-IN-9;GSK2110183 analog 1;MS5033

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