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ML 145

CAS No. : 1164500-72-4

Biological Activity：ML 145 is a selective and competitive human GPR35/CXCR8 antagonist with an IC₅₀/EC₅₀ of 20.1 nM. ML 145 has over 1000-fold more selective for GPR35 compared to GPR55 (IC₅₀/EC₅₀=21.7 μM). ML 145 has no significant activity for GPR35 at either rodent ortholog^[2].

Research Area：Inflammation/Immunology|Endocrinology

Targets：CXCR|GPR35

Related Screening Libraries:Bioactive Compound Library Plus;GPCR/G Protein Compound Library;Immunology/Inflammation Compound Library;Small Molecule Immuno-Oncology Compound Library;Endocrinology Compound Library;Targeted Diversity Library;Chemokine Compound Library;

Related Small Molecules:Nicotinamide N-oxide;FC131;CXCR4 antagonist 2;AMG 487 (S-enantiomer);CXCR4 antagonist 6;CXCR2 antagonist 4;VUF11207 fumarate;KRH-3955 hydrochloride;IT1t dihydrochloride;CID1231538;NBI-74330;MSX-130;SCH 546738;Elubrixin;CXCR2 antagonist 2;CXCR2-IN-1;Mavorixafor;HF51116;Reparixin L-lysine salt;HF50731;AZD-5069;AZD8797;BAM-12P;CTCE-0214;Baohuoside I;Ladarixin sodium

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