Keap1-Nrf2-IN-8

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Keap1-Nrf2-IN-8

CAS No. : 2769963-54-2

Biological Activity:Keap1-Nrf2-IN-8 (compound 12d) is a potent Keap1-Nrf2 PPI (Keap1-Nrf2 protein−protein interaction) inhibitor with IC50s of 64.5 nM and 14.2 nM for FP and TR-FRET assays, respectively. Keap1-Nrf2-IN-8 significantly increases the mRNA levels of Nrf2 downstream genes, GSTM3, HMOX2 and NQO1.

Research Area:Inflammation/Immunology

Targets:Keap1-Nrf2

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