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JNJ-26070109

CAS No. : 844645-08-5

Biological Activity：JNJ-26070109 is a high-affinity, competitive, orally bioactive, and selective cholecystokinin 2 (CCK2) receptor antagonist with good pharmacokinetic properties, with pK_is of 8.49, 7.99, and 7.70 for human, rat, and dog CCK2 receptors, respectively. The dual function of CCK2 receptors in regulating gastric acid secretion and growth of the gastrointestinal mucosa make this an attractive and novel target for the treatment of gastroesophageal reflux disease.

Research Area：Metabolic Disease

Targets：Cholecystokinin Receptor

Related Small Molecules:Loxiglumide;Gastrin I, human;(Rac)-Sograzepide;Nastorazepide;Proglumide;Lorglumide sodium salt;LY288513;Tarazepide;L-365260 hemihydrate;Mini Gastrin I, human TFA;CCK-B Receptor Antagonist 2;CI-988;Gastrin I, rat;CHEMBL333994;Gastrin/CCK antagonist 1;Dexloxiglumide;N-acetyl CCK-(26-30) amide;Tetragastrin;Sograzepide-d3;SR 146131;Lintitript;A71623;GI 181771;Devazepide

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