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H3B-5942
CAS No. : 2052128-15-9
Biological Activity：H3B-5942 is a selective, irreversible and orally active estrogen receptor covalent antagonist, inactivates both wild-type and mutant ERα by targeting Cys530, with Kis of 1 nM and 0.41 nM, respectively. H3B-5942 reduces ERα target gene GREB1, shows potent antitumor activity both in multiple cell lines or animals bearing ERαWT or ERα mutations.
Research Area：Cancer
Targets：Estrogen Receptor/ERR
Related Screening Libraries:Covalent Screening Library Plus;Bioactive Compound Library Plus;Anti-Cancer Compound Library;Covalent Screening Library;Orally Active Compound Library;Anti-Breast Cancer Compound Library;Nuclear Receptor Compound Library;
Related Small Molecules:DS20362725;LSD1/ER-IN-1;Giredestrant;Avobenzone;Estriol-d3;Chrysin;ERRγ Inverse Agonist 1;(R)-DPN;MPP hydrochloride;GPR30 agonist-1;Diethylstilbestrol;Endoxifen;Glicoricone;ERB-196;Dihydroresveratrol;FLTX1;(Rac)-Hexestrol-d6
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