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GSK2646264

CAS No. : 1398695-47-0

Biological Activity：GSK2646264 (Compound 44) is a potent and selective spleen tyrosine kinase (SYK) inhibitor with a pIC₅₀ of 7.1. GSK2646264 also inhibits other kinases with pIC₅₀ values of 5.4, 5.4, 5.3, 5, 4.5, <4.6 and <4.3 against LCK, LRRK2, GSK3β, JAK2, VEGFR2, Aurora B and Aurora A, respectively. GSK2646264 is penetrable into the epidermis and dermis of the skin.

Research Area：Inflammation/Immunology

Targets：JAK|VEGFR|GSK-3|Src|Aurora Kinase|Syk|LRRK2

Related Screening Libraries:Clinical Compound Library Plus;Bioactive Compound Library Plus;

Related Small Molecules:AZ-3;(Z)-FeCP-oxindole;DB0614;TCS2002;KB SRC 4;Tirbanibulin dihydrochloride;JAK3/BTK-IN-1;VEGFR-2-IN-24;AR-A014418;BMS-690514;AT9283;Benzene hexabromide;Bafetinib;PROTAC VEGFR-2 degrader-2;(E/Z)-Zotiraciclib;p60c-src substrate II;Henatinib;JAK-IN-10;Baricitinib-d3;PI3K/VEGFR2-IN-1;JAK3-IN-6;Caffeic acid-pYEEIE TFA;PP2;GSK 3 Inhibitor IX;Coumermycin A1

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