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FLT3-IN-12

CAS No. : 2499966-67-3

Biological Activity：FLT3-IN-12 is a potent, selective and orally active FLT3 kinase inhibitor with IC₅₀s of 1.48 nM and 2.87 nM for FLT3-WT and FLT3-D835Y, respectively. FLT3-IN-12 possesses high selectivity over c-KIT (>1000-fold). FLT3-IN-12 has an excellent anti-AML (acute myeloid leukemia) activity (MV4-11, IC₅₀ of 0.75 nM).

Research Area：Cancer

Targets：FLT3

Related Small Molecules:AT9283;(E/Z)-Zotiraciclib;Crotonoside;FLT3-IN-13;PDGFRα/FLT3-ITD-IN-2;FLT3/CDK4-IN-1;HP1142;ENMD-2076 Tartrate;ATH686;AZD2932;AKN-028 acetate;FLT3-IN-3;UNC2025 hydrochloride;Tandutinib;Gilteritinib-d8;PF 477736;(R)-3-Hydroxy Midostaurin;BSc5371;OTS447;PDGFRα/FLT3-ITD-IN-1;TAK-659 hydrochloride;FLT3-IN-4;JNJ-47117096 hydrochloride;FLT3-IN-14;MAX-40279 hemiadipate

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