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FK888

CAS No. : 138449-07-7

Biological Activity：FK888 is a potent, selective, and high affinity dipeptide NK1 receptor antagonist. FK888 displaces [3H]-SP binding with a K_i value of 0.69 nM and 0.45 microM. FK888 also inhibits SP-induced airway oedema in guinea-pig after both intravenous and oral administration.

Research Area：Inflammation/Immunology

Targets：Neurokinin Receptor

Related Small Molecules:(β-Ala8)-Neurokinin A (4-10);Talnetant hydrochloride;Pavinetant;MEN11467;(D-Arg1,D-Pro2,D-Trp7,9,L-Leu11)-Substance P;Vapreotide acetate;Rolapitant;Eprazinone dihydrochloride;Orvepitant maleate;Netupitant metabolite Monohydroxy Netupitant;SB-222200;Senktide;GR 87389;Hemokinin 1, human;Neurokinin A TFA;Imnopitant dihydrochloride;[Glp6] Substance P (6-11);[Lys5,MeLeu9,Nle10]-NKA(4-10) TFA;[Pro9]-Substance P;Befetupitant;Hemokinin 1 (mouse);Substance P Receptor Antagonist 1;(D-Pro2,D-Trp6,8,Nle10)-Neurokinin B;Substance P (1-9);(D-Arg1,D-Pro2,D-Phe7,D-His9)-Substance P;Substance P-Gly-Lys-Arg

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