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Fenbendazole
CAS No. : 43210-67-9
Biological Activity：Fenbendazole is an orally active benzimidazole anthelmintic agent, with a broad antiparasitic range. Fenbendazole is a microtubule destabilizing agent and acts on helminthes primarily by binding to tubulin and disrupting the tubulin microtubule equilibrium. Fenbendazole stabilizes the transcriptional activator HIF-1α. Fenbendazole possesses an efficient anti-proliferative activity and induces apoptosis. Fenbendazole causes cell-cycle arrest and mitotic cell death, and has antitumor activity in mice xenografted with wild-type p53.
Research Area：Infection
Targets：Parasite|Microtubule/Tubulin|HIF/HIF Prolyl-Hydroxylase|Antibiotic
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