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EIPA hydrochloride
CAS No. : 1345839-28-2
Biological Activity：EIPA (L593754) hydrochloride is an orally active TRPP3 channel inhibitor with an IC50 of 10.5 μM. EIPA hydrochloride also enhances autophagy by inhibiting Na+/H+-exchanger 3 (NHE3). EIPA hydrochloride inhibits macropinocytosis as well. EIPA hydrochloride can be used in the research of inflammation and cancers, such as gastric cancer, colon carcinoma, pancreatic carcinoma[2][3][5].
Research Area：Cancer|Inflammation/Immunology
Targets：Autophagy|Prostaglandin Receptor|TRP Channel|Na+/H+ Exchanger (NHE)|COX
Related Screening Libraries:Bioactive Compound Library Plus;GPCR/G Protein Compound Library;Immunology/Inflammation Compound Library;Membrane Transporter/Ion Channel Compound Library;Neuronal Signaling Compound Library;Anti-Cancer Compound Library;Autophagy Compound Library;Anti-Aging Compound Library;Pyroptosis Compound Library;Orally Active Compound Library;Anti-Pancreatic Cancer Compound Library;Angiogenesis-Related Compound Library;Mechanoreceptors Compound Library;Anti-Colorectal Cancer Compound Library ;Antidepressant Compound Library;Human Metabolite Library;Anti-Prostate Cancer Compound Library;
Related Small Molecules:V116517;Akt/NF-κB/JNK-IN-1;COX-2/5-LOX-IN-3;GSK2332255B;Pregnenolone monosulfate sodium;TRPC5-IN-4;OptoBI-1;Omidenepag isopropyl;Ampyrone;COX-2-IN-24;DG-041;Cariporide;Zaltoprofen-d7;SB-705498;8-Isoprostaglandin E2;BAY-6672;trans-Isoferulic acid;TRPC3/6-IN-1;ABT-239;Pyr3;GSK-269984A;KMN-80;α-Vitamin E-d6;1-Hydroxy-ibuprofen;Asaraldehyde;Asivatrep;(-)-Epicatechin;20(S)-Ginsenoside Rg3
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