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DSM705 hydrochloride

Biological Activity：DSM705 hydrochloride, an orally active antimalarial compound, is a pyrrole-based Dihydroorotate Dehydrogenase (DHODH) inhibitor. DSM705 hydrochloride exhibits nanomolar potency against Plasmodium DHODH and Plasmodium parasites (IC₅₀=95, 52 nM for P. falciparum and P. vivax DHODH, respectively), with no inhibition of mammalian DHODHs.

Research Area：Infection

Targets：Parasite|Dihydroorotate Dehydrogenase

Related Screening Libraries:Bioactive Compound Library Plus;Anti-Infection Compound Library;Metabolism/Protease Compound Library;Ferroptosis Compound Library;Orally Active Compound Library;Antiparasitic Compound library;Mitochondria-Targeted Compound Library;

Related Small Molecules:(+)-Isopulegol;SR9186;Antileishmanial agent-2;Azlocillin sodium salt;SQ109;Trypanothione synthetase-IN-3;P1788;Pyrantel;α-Terpinene;Dehydrocorydaline;Niclosamide monohydrate;Febrifugine dihydrochloride;Antimalarial agent 15;Cycloguanil hydrochloride;Anti-infective agent 6;Morantel tartrate;Sulfiram;UCB7362;Retro-2;PfDHODH-IN-2

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