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Desmethylglycitein
CAS No. : 17817-31-1
Biological Activity：Desmethylglycitein (4′,6,7-Trihydroxyisoflavone), a metabolite of daidzein, sourced from Glycine max with antioxidant, and anti-cancer activities.
Desmethylglycitein binds directly to CDK1 and CDK2 in vivo, resulting in the suppresses CDK1 and CDK2 activity. Desmethylglycitein is a direct inhibitor of protein kinase C (PKC)α, against solar UV (sUV)-induced matrix matrix metalloproteinase 1 (MMP1)[2]. Desmethylglycitein binds to PI3K in an ATP competitive manner in the cytosol, where it inhibits the activity of PI3K and downstream signaling cascades, leading to the suppression of adipogenesis in 3T3-L1 preadipocytes[3].
Research Area：Cancer
Targets：CDK|PKC|PI3K
Related Screening Libraries:Natural Product Library Plus;Bioactive Compound Library Plus;
Related Small Molecules:DB0614;[Ala107]MBP(104-118) TFA;Umbralisib hydrochloride;BJE6-106;Dinaciclib;Myelin Basic Protein;Staurosporine;SNS-032;Topoisomerase I/II inhibitor 3;CC-671;PKC-iota inhibitor 1;(E/Z)-Zotiraciclib;Rigosertib sodium;Tenalisib R Enantiomer;CDK1-IN-4;CCT-251921;BS-181;Samuraciclib hydrochloride hydrate;PI3kδ inhibitor 1;Hypericin;PI3K/VEGFR2-IN-1;Malantide;PKCiota-IN-2 formic;T025;Flavopiridol;CDK8-IN-3
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