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Deguelin
CAS No. : 522-17-8
Biological Activity：Deguelin, a naturally occurring rotenoid, acts as a chemopreventive agent by blocking multiple pathways like PI3K-Akt, IKK-NF-κB, and MAPK-mTOR-survivin-mediated apoptosis. Deguelin binding to Hsp90 leads to a decreased expression of numerous oncogenic proteins, including MEK1/2, Akt, HIF1α, COX-2, and NF-κB.
Research Area：Cancer
Targets：Akt|Autophagy|Apoptosis
Related Screening Libraries:Natural Product Library Plus;Bioactive Compound Library Plus;Apoptosis Compound Library;Kinase Inhibitor Library;NF-κB Signaling Compound Library;PI3K/Akt/mTOR Compound Library;Stem Cell Signaling Compound Library;Natural Product Library;Anti-Cancer Compound Library;Autophagy Compound Library;Anti-Aging Compound Library;Differentiation Inducing Compound Library;Lipid Compound Library;Oxygen Sensing Compound Library;Glycolysis Compound Library;Cytoskeleton Compound Library;Glutamine Metabolism Compound Library;Traditional Chinese Medicine Active Compound Library;Flavonoids Library;Anti-Breast Cancer Compound Library;Anti-Lung Cancer Compound Library;Anti-Pancreatic Cancer Compound Library;Anti-Blood Cancer Compound Library;Anti-Cancer Metabolism Compound Library;Anti-Obesity Compound Library;Angiogenesis-Related Compound Library;Glucose Metabolism Compound Library;Food-Sourced Compound Library ;Anti-Liver Cancer Compound Library ;Anti-Colorectal Cancer Compound Library ;Anti-Cancer Natural Product Library;Plant-Sourced Natural Product Library;Human Metabolite Library;Anti-Prostate Cancer Compound Library;Anti-Pulmonary Fibrosis Compound Library;Cancer Stem Cells Compound Library;
Related Small Molecules:Physalin A;Bomedemstat ditosylate;Akt/NF-κB/JNK-IN-1;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;BJE6-106;Dinaciclib;Ecteinascidin 770;MDM2-p53-IN-15;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8;Topoisomerase I/II inhibitor 3;Xevinapant;Mangiferin;Cambinol;Antioxidant agent-5;Apoptosis inducer 9;Bafetinib;Cyclovirobuxine D;STAT3-IN-10
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